An Autopsy Case of Rapidly Progressive Glomerulonephritis with vasuculitis

Abstract

A case (44 yrs. female) of rapidly progressive glomerulonephritis with vasculitis in various organs was reported with special reference to the histopathogenesis of the development of the extracapillary disorganizing glomerulonephritis. Severe exudation with massive fibrinoid material into the Bowmann's space was observed in local and segmental glomerular loops. This was followed by the granulomatous proliferative reaction in the Bowman's space as well as from the pericapsular interstitium, resulting in the destruction of the glomerular structure. Etiopathogenesis of vasculitis and glomerulitis was discussed with reference to the findings in some experimental glomerulonephritides.