Abstract
A 60-year-old man had a renal stone of uric acid component with the laboratory findings of hypouricemia (1.1-2.0 mg/100 ml), hyperuricosuria (700-1600 mg/day), and an increased uric acid clearance (43 ml/min). This combination of metabolic abnormalities may be the results of hyperexcretion of uric acid associated with the tubular reabsorptire defect. Similar case with renal stone has not yet been reported to date.Although it has already been known that a significant group of patients with uric acid calculi do not have hyperuricemia or increased uric acid excretion, uric acid renal stone is occasionally formed in hyperuricosuric condition. Hyperexcretion of uric acid associated with hypouricemia is an infrequent abnormality of uric acid metabolism. We herein present a rare case of renal stone with the laboratory findings of both hypouricemie hyperuicosuria, and tubular reabsorptive defect of uric acid.
