Abstract
1. Annria developed in patients whose the left kidney has been removed for nephrolithiasis 25 years ago. On examination biliary calculi were found. 2. After fourty days rabbits were subjected to removal of one kidney and to operation, a 6 per cent lycopodium suspension prepared with physiological saline was injected directly into the liver in order to cause liver impairment. Oliguria or anuria was also observed. 3. After the removal of one kidney, the compensatory hypertrophy of the remaining kidney usually takes place. However, such a hypertrophy did not take place in the kidney of rabbits whichh were affected with oliguria or anuria. This might be due to the fact that experimental hepatic impairment prevents the remaining kidney from performing its compensatory function. 4. Various qualitative tests were repeatedly carried out in the urine of rabbits in which the experiments were performed. Study of the urine for protein and indican alone revealed positive. Generally speaking, there were no such findings as were interpreted as abnormal. 5. Rabbits in which anuria or oliguria developed showed an increase in the non-protein nitrogen value. An increase in the urinary nitrogen value took place in moiety of the rabbits. An increase in the non-protein nitrogen value is due to liver insufficiency, whereas an increase in the urinary nitrogen value is due to renal insufficiency. 6. The testing of liver function by the schema of Bruger and Oppenheim showed that alkaline ph.osphatase activity markedly diminished. Even if the liver is impaired, its conservative function is so high that tests do not easily produce abnormal results. 7. As an indicator of liver insufficiency, Ratliff paid an attention to be important to an increase in amount of amino-acid nitrogen and a decrease in the blood sugar level following hepatorenal syndrome. However, a decrease in the blood sugar level did not occur at all in our experiments. 8. As for electrolytes in the blood, there was an increase in amount of kalium and a decrease in amount of natrium. These findings were similar to those which were encountered in the case of acute renal insufficiency. 9. Pathohistological examination of the kidney affected with anuria or oliguria disclosed the swelling and hyaline droplet degeneration of the renal tubular epithelium. Well-defined patches of coagulation necrosis were noted at the site of injection in the liver. On Glisson's capsule an infiltration of a small number of round cells was accompanied by the muitiplication of minute biliary ducts. 10. The 24-hour urinary excretion of 6-hydroxyindole acetic acid lays in a normal range.
