Abstract
The urinary excretion of fibrin/fibrinogen degradation products (FDP) were measured by the method of the tanned red cell hemagglutination inhibition immunoassay (TRCHII) in 54 patients with nephrotic syndrome. More than 4.Eg/ml of urinayFDP was regarded as positive. The results obtained were as follows : (1) Idiopathic and nephritic nephrotic syndrome (a) Urinary FDP positive cases were found in nephrotic patients more than in non-nephrotic patients. (b) The urinary FDP excretion did not correlated with fibrin on immunofluorescent studies. (c) The values of serum FDP in nephrotic patients were within normal limit and did not correlated with the amount of urinary FDP. (d) Serum fibrinogen and serum lipid levels were higher in nephrotic patients than in nonnephrotic patients, but there was not significant difference between urinary FDP positive cases and negative cases. (e) In six patients whose urinary FDP showed persistent positive five patients showed partial remission but one patient became uremic. (2) Lupus nephritis Nephrotic syndrome due to lupus nephritis had more urinary FDP positive cases than nonnephrotic syndrome. Urinary FDP positive cases with nephrotic syndrome showed active lesions by the histological examination. (3) Diabetic nephropathy Two positive cases of urinary FDP showed decreased renal function. (4) Renal amyloidosis Five of seven nephrotic patients showed urinary FDP positive.
