Imunological study in IgA Nephropathy

Abstract

Immunological study in IgA Nephropathy, characterized by the finding of IgA, predominantly inn the mesangium, was performed in 46 patients without evidence of systemic diseases. The following results were obtained, 1. It was supported that by immunofluorescent study, the activation of complement in IgA Neph ropathy was induced mainly by the alternative pathway. 2. In immunoserological study, no any characteristic findings were found in IgA Nephropathy. 3. It was considered that further studies are necessary to clarify the relationship between IgA and the mechanism of mesangium in IgA Nephropathy.