Intestinal Absorption of Iron in Experimental Renal Failure Rat

Abstract

Factors affecting the intestinal absorption of ⁵⁹Fe in a uremic state were investigated by using the everted gut sacs of renal failure (RF) rats with 30% GFR and normal rats. The duodenal absorption of ⁵⁹Fe was significantly lower in the (RF) rats than in the normal rats, while the colonic absorption of ⁵⁹Fe did not differ between the two groups. The absorption of ⁵⁹Fe in the duodena of the normal rats was significantly lower after the addition of sera from non-dialyzed uremic patients than after the addition of sera from hemodialyzed uremic patients. The absorption of ⁵⁹Fe in the duodena of the normal rats was significantly lower after the addition of sera from uremic patients under hemodialysis (HD) than after the addition of sera from uremic patients under continuous ambulatory peritoneal dialysis (CAPD). The absorpton of ⁵⁹Fe in the duodena of the normal rats was not altered by the separate addition of urea, creatinine, methylguanidine (MG) and guanidinosuccinic acid (GSA), but became significantly lower after the addition of the mixture of these substances.