Immunoglobulin A associated idiopathic glomerulonephrits in children and adults: clinicopathology and immunopathology

Abstract

The clinical and pathologic features of 45 patients with immunoglobulin A (IgA) nephropathy were reviewed in a total of 170 biopsies. These patients were divided into two groups according to the sites of the predominant immunoglobulin deposits in the glomerulus.: Group 1 (mainly seen along the glomerular capillary. 25 patients) and Group 2 (in the mesangium. 20 patients).1) Predominant incidence of male over female was noted in both group's patients. The mean years was younger in Group 1 (16.4 years) than in Group 2 (24.1 years).2) A significant correlation with severel fight microscopic findings was found for a) proteinuria+hematuria. b) high IgA serum leveles. c) patients over fifteen years old, d) the long duration of symptomes befor biopsy (ten monthes or more). e) the cases of Group 2.3) On immunofluorescence, a predominant presence of granular deposits of both IgA and fibrinogen on the basement membrane was particulary characteristic and almost constant in cases of Group 1 (88%).