Clinical studies on nephrotic syndrome after renal transplantation

Abstract

Proteinuria and nephotic syndrome frequently occur after renal transplantation We analyzed clinical and histo-pathologic data from 14 recipients (12 living and 2 cadaveric) who developed nephotic syndrome out of 90 living and 11 cadaveric renal grafts surviving over 3 months. Nephrotic syndrome was developed at 22.4 (mean) months post-transplant (range, 3 to 65 months) . The cause of nephrotic syndrome was attributed to transplant glomerulopathy of chronic rejection in 13 recipients and 1 case of renal vein thrombosis. After the onset of nephrotic syndrome, graft f unction deteriorated rapidly, with a 1 year graft surval of 36% and a 2 year graft survival of 10%. Histological characteristics of transplant glomerulopathy was variable capillary wall lesion. Multiple splitting of glomerular capillary wall as a result of subendothelial cell injury and expansion of subendothelial electron lucent layer was common finding.