1986 Volume 28 Issue 6 Pages 763-775
We have carried out simultaneous measurement of cardiac output, regional blood flows and intrarenal blood flow distribution, using microsphere technige in the glycerol-induced acute renal failure in the water-drinking (water group), 0.9% NaCl-drinking for 4 weeks (saline group), 0.1% captopril-drinking (captopril group) rats. In all groups, cardiac output, renal blood flow and the other regional blood flows significcantly decreased 4 hours after glycerol injection. Intrarenal blood flow redistribution from outer cortex to inner cortex was occured. At 10 hours after glycerol injection, cardiac output, renal blood flow and liver blood flow returned to almost the control values only in the saline group, but still remained significantly lower in the other groups. Intrarenal blood flow redistibution toward inner cortex was still persisted in the all groups. Not only acute renal failure but also hepatic disorder were evident, as indicated by significantly elevated mean BUN and GPT values in the water and the captopril groups. However the protection of not only acute renal failure but also hepatic disorder was recognized in the saline group. The above results suggest that the systemic hemodynamics changes relate to the development of acute renal failure and that the rapid recovery not only renal blood flow but also liver blood flow would be important to prevent the development of acute renal failure.
