A case of hypocomplementemic mesangiocapillary glomerulonephritis: Appearance of C3 NeF and another factor

Abstract

A patient with hypocomplementemic mesangiocapillary glomerulonephritis had two different coexistent serum factors, which may be able to activate the alternative complement pathway: One was immunologically identical with C3 nephritic factor and the other was a non-IgG factor. In this case, the changes in the complement system indicated that the level of C5 was extremely reduced at the time when the two factors appeared, while the CS levels were almost normal only when C3 nephritic factor appeared.