The effects and pharmacokinetics on ventricular arrhythmias of Mexiletine in maintenance hemodialysis patients

Abstract

Administration of Mexiletine were performed in 7 patients with hige grade ventricular arrythmias (over Lown grade 3) who were recived maintenance hemodialysis. The change rate of 3 cases showed over 33% in number of VPC during 24 hours, Also, 5 of 7 cases inproved on Lown grade, and 6 of 7 cases inproved on clinical symptons, other one case had unchanged. Mexiletine was removed during hemodialysis, why Mexiletine clearance was 42.4± 10.7 ml/min, Blood chemical parameters and mean arterial pressure were unaffected by administration of Mexiletine, Administration of Mexiletine was comparatively safety on main-tenance hemodialysis patients.