The Japanese Journal of Nephrology
Online ISSN : 1884-0728
Print ISSN : 0385-2385
Carbon tetrachloride (CCl4) induced tubulo-interstitial renal lesions in mice
TERUO MORIYOSHIO MORIMAKOTO OGAWASHIRO UEDAHIROMICHI YOSHIDAISAO KATORYOSAKU AZEMOTOKENJI IESATOYOKO WAKASHINMASAFUMI WAKASHINKUNIO OKUDA
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1987 Volume 29 Issue 8 Pages 981-987

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Abstract
Tubulo-interstitial renal lesions were definitely induced in BALB/c mice and moder-ately induced in C3H/He mice but not in C57BL/6 mice by several intraperitoneal injections of carbon tetrachloride (CCl4).In the sera of CCl4-treated mice with renal lesions, anti-renal tubular epithelium (RTE) autoantibody was detected. Induction of these renal lesions was strongly inhibited by the pretreatment of whole body irradiation at 300 rad. And the presence of anti-RTE autoantibody in the sera of CCl-treated mice and the degree of blast formation of spleen cells from these animals were also markedly decreased by the irradiation. According to these results, induction of tubulo-interstitial renal lesions seen in the CCl4-treated mice seems to be derived from strain variation of sensitivity to CCl4 and be caused by the combination of direct cytotoxic effects of CC14 and radiosensi-tive immune systems activated by this agent.
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© Japanese Society of Nephrology
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