A case of nephropathy caused by hypothyroidism

Abstract

We conducted renal biopsy on a 36-year-old male patient with hypothyroidism accompanied by proteinuria (0.3-0.4/day) and renal failure (Ccr 41.2 ml/min). Light microscopically, thickening of glomerular capillary wall, expansion of mesangial area and seal-engraving change due to the deposition of lipid were observed both diffusely and globally. Electron microscopically, loosening of GBM (Lamina rara interna) and mesangial matrix, and vacuolization of mesangial cell were noted. Based on the literature available heretofoe, glomerular plathology of nephropathy is considered to have been caused by hypothyroidism. We decided to report on this case inasmuch as, to the writer's knowledge, findings on the relationship between hypothyroidism and renal pathology are scarce both home and abroad.