Renal hemodynamic effect of angiotensin II type 2 receptor

Abstract

In the present study, the role of the angiotensin II type 2 receptor in the regulation of medullary blood flow in conscious Spontaneous Hypertensive Rats (SHR) was investigated. We tested the hypothesis that AT2 receptor activation may exert the opposite effects of AT 1 recptors in terms of renal hemodynamics. Mean arterial pressure (MAP), daily sodium balance, cortical blood flow (CBF), and medullary blood flow (MBF) were measured over a 10-day protocol in several groups of rats in which optical fibers for laser-Doppler Flowmetry had been implanted and which received the following drug combinations the AT1 receptor antagonist CV 11976 (CV) alone and CV plus AT2 receptor antagonist PD 123319 (PD). In the CV alone group, the renal interstitial administration of CV decreased MAP, caused sodium diuresis, and increased MBF significantly. In the CV plus PD group, the renal interstitial administration of PD prevented sustained hypotension, sodium diuresis, and increased medullary blood flow during CV administration. These data indicated that AT2 receptor activation leads to vasodilation in the renal medulla and an antihypertensive effect in SHR. AT2 receptors play an important role in the renal medullary blood flow.