1955 Volume 46 Issue 9 Pages 639-649
The acid and alkaline phosphatase reactions of neutrophilic leucocytes in peripheral blood smears were investigated histochemieally in 18 cases of prostatic hypertrophy, 9 cases of prostatic tumor and 16 cases of bladder carcinoma, and the acid and alkaline phosphatase activities determined chemically.
1) The acid and alkaline phosphatases of leucocytes in prostatic hypertrophy generally showed normal values. In prostatic hypertrophy with complications of serious inflamations or abuormal metabolism, however, the increasing of phosphatase content in leucocytes were observed.
2) In some cases of advanced prostatic carcinoma, the acid and alkaline phosphatase activity of serum and the phosphatase reactions of leucocytes increased together.
3) In the prostatic carcinoma treated with castration or high unit estrogenic hormonal the rapy, the remission of clinical symptoms was recognized, and in half of the cases, the acid phosphatase activity of serum and the phosphatase reactions of leucocytes became normal simultaneously.
4) The acid phosphatase activity of serum in cases operated with total prostatectomy did not show any recognizable change. This seems to suggest that there were some remaining carcinoma or metastases.
5) The phosphatase activity of serum in cases of bladder carcinoma generally had normal values, and the phosphatase reactions of leucocytes were intensified in many cases of advanced bladder carcinoma.
6) It is considered that the increase of phosphatases in leucocytes in these cases was caused by complications of inflamatory lesions, and the decrease of the phosphatase in leucocytes followed. the recovery of such complications. The phosphatase of leucocytes seems to have very intimate relations with inflamatory or carcinomatous lesions.
