A STUDY OF THE AUTOTRANSPLANTED NECK KIDNEY IN THE DOG

I. REPORT; ON THE RENAL FUNCTION IMMEDIATELY AFTER TRANSPLANTATION

Abstract

The function of the autotransplanted neck kidney for 3 hours after transplantation were examined by measuring renal clearance and renal extraction ratio.
The results were as follows:
(1) The transplanted kidney began to function shortly after the operation and the renal function was restored considerably within a few hours.
(2) Urinary secretion from the transplanted kidney was perceptible after the operation within a half on an average 26.5 minutes.
The rate of urine output was 0.067 to 1.87cc/min, the specific gravity ranged 1010 to 1028 and the reaction of the urine was alkalin. Though the urine secretion is the most important of the renal function, we cannot justly appreciate the renal function only by the rate of secretion.
(3) The renal blood flow was severely impaired in the transplanted kidney. It amounted only 60% of the normal value 3 hours after the transplantation, even in the most favorable cases. The tubular function was damaged, also. In the favorable cases EPAH was 80% of the normal value. The impairment of glomerular function was minimum, as a normal measurement was obtained in the favorable cases.
(4) Such renal damages may be due to unavoidable renal anoxia during the procedures of transplantation, duration of which lasted 43.0 minutes on an average. Anastomotical techniques of the blood vessels and denervation may be the contributory factors to the renal damages.
(5) These results indicate that the homotransplantation of the kidney is clinically applicable.