STUDIES ON INFLUENCE OF THE VASECTOMY

REPORT II, EXPERIMENTAL STUDIES; HISTOLOGIC AND ENDOCRINOLOGIC RESEARCHES ON INFLUENCES OF THE VASECTOMY

Abstract

This is a study on the influence of the vasectomy in albino rats by histological, biochemical and histochemical examinations.
1) Histologically, there was little change in the spermatospare, spermatocyte and sertoli cell after a vasectomy. However, the development of sperma from spermatid was impeded. This phenomenon increased gradually after the operation for 8 to 12 weeks, but reduced 20 weeks after the operation.
In the interstitial tissue the roughness and edema of connective tissue, and the proliferation of interstitial cells were observed nearly parallel to the change in the spermatogenesis.
2) An enlargement of the gland cavity and an increase of gland contents were recognized in epididymis. A hypertrophy of the epithelial cell in spermatic cord, and a constriction of the gland cavity in seminal vesicle and prostate, were also recognized.
3) Changes in the young albino rats were almost the same as the changes in mature animals, though the changes were apt to be slightly milder in the former. In young animals the testis fully developed with the general maturity even after the surgery.
4) When the testosterone propionate is given to mature rats after the vasectomy, the spermatogenesis is more definitely inpeded than in those with simple vesectomy.
5) The ligature and cutting of circumferential tissue with the spermatic cord, caused an atrophy of the testis of the same side in the majority of rats.
6) In the histochemical and biochemical observations, the slight lowering of Alkali-Phosphatase activity of seminiferous tubule and the slight rise of β-Glucuronidase activity of seminal vesicle were seen in the mature rats after the vasectomy.
In young animals there was a rise of β-Glucuronidase activity of testis but no definite change in the lipase and esterase.
No definite changes were observed neither in the accessory sexual gland nor in other organs.