1959 Volume 50 Issue 4 Pages 333-343
Histological and arteriographical examinations were made of kidneys homotransplanted into the neck of dogs of uremic condition caused by bilateral nephrectomy and following conclusions were drawn.
1) Most of homotransplanted kidneys revealed as good an arterial circulation as in autografted kidneys on the period immediately after grafting. Intrarenal vasospasm, however beginns 3 or 4 days after homografting and it goes on to extreme grade with cortical ischemia when anuria sets in. This is considered as the main factor of the cease of renal function.
2) Histology in most cases revealed cell infiltration, consisting mainly of lymphocyte in interstitial tissue and accumulation of intratubular secretion, while most glomeruli sustained no pathological changes and tubular cells did not reveal degeneration and/or necrosis to the extreme degree.
3) Less histological change of homotransplanted kidneys to the uremic dogs than that to the healthy dogs was consisted to be based on decreased immunological reaction due to uremia.
4) The series of my experiments proved that the homotransplanted kidney was one of the valuable procedures in case of acute renal insufficiency for temporary compensation.
