STUDIES ON RENAL HYPERTENSION
REPORT II. INVESTIGATION ON SERUM AND URINE ELECTROLYTES IN RENAL HYPERTENSION
1964 Volume 55 Issue 12 Pages 1275-1291
Details
1964 Volume 55 Issue 12 Pages 1275-1291
Serum electrolytes (K, Na, and Cl) were measured in 128 cases of urological diseases (17 of them complicated with renal hypertension, 20, extrarenal hypertension), 52 cases of essential hypertension, 15 normal persons, 11 Goldblatt's rabbits, 7 Goldblatt's dogs, 3 nephrectomized rabbits and 2 nephrectomized dogs, and the relationships among serum electrolytes, renal function and blood pressure were investigated. Futhermore, in some cases, measurements of urine volume and electrolytes, and the load test of isotonic or hypertonic saline were performed. The results were as follows.
1) Serum electrolytes in renal hypertension which were generally in the normal range, showed no significant difference from those of normal persons, those of ptients with non-hypertensive urological diseases and essential hypertension and no correlation with blood pressure or renal function.
2) Urine electrolytes showed no consistent results because of their large daily variations. They seemed not related with blood pressure but related with renal function or renal vascular condition. At least, no specific pattern of urine electrolytes was noticed in renal hypertension.
3) Na and Cl in urine temporally decreased when blood pressure was discending, on the other other hand, temporally increased when blood pressure was increasing.
4) Some cases of hypertension showed diuresis and increased excretion of Na and Cl by load if physiologic saline, but no specific reaction was observed in renal hypertension.
5) Changes in urine volume and urine electrolytes after load of hypertonic saline were not consistent and no specific reaction was observed in renal hypertension.
6) Intravenous or oral continuosus administration of saline in normotensive Goldblatt's rabbits brought a temporal increase in blood pressure 3 to 5 days after the begining of administration.
In conclusion, no specific pattern of electrolyte metabolism in renal hypertension was noticed from observations of serum and urine electrolytes. It seemed that the disturbance of electrolyte metabolism was not the essential factor in the development of renal hypertension.
