1965 Volume 56 Issue 10 Pages 1137-1146
AMCHA, described chemically as 4-aminomethylcyclohexane-1-carboxylic acid, was developed by professor Okamoto, and was found more powerful than ε-aminocaproic acid in antifibrinolytic activity. Recent investigations have revealed that there are two typs of stereo-(isomers) of AMCHA, cis-and transand especially the latter has potent antifibrinolytic activities, among which the suppression of plasminogen activator is prominent. We have tested trans-AMCHA in the treatment of the following urological disoders and have obtained considerably good results. I. Idiopathic renal bldeeing. II. Bleeding from renal tumor, and Surgery upon the renal parenchyma III. Surgery upon the prostatic hypertrophy IV. Others.
Having a powerful suppressive action of plasminogen activator, trans-AMCHA enhnces the hemostatic effect in the hemorrhagic condition resulting from an elevated plasmin activity by producing aquite rapid coagulation.
