A STUDY ON CORRELATIONSHIP BETWEEN RENAL CLEARANCE AND RENAL BIOPSY IN THE AGED UROLOGICAL PATIENTS
1965 Volume 56 Issue 3 Pages 249-268
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1965 Volume 56 Issue 3 Pages 249-268
This study was carried out to clarify the correlation between the function and the histology of the kidney in the aged, as well as to examine the effect of the surgical operation on the kidney function.
From 593 persons with the age over 60 admitted to our clinic, 100 patients were selected for the experiment. Three younger patients were used for controlling subjects.
Renal biopsy was performed in these patients with Vim-Silverman needle (Kark), obtaining more than 7 glomeruli. For clearance tests, G. F. R. and R. P. F. were measured, using sodium thio-sulfate and para-aminohippurate respectively.
Comparison of the values of the renal clearances wih the findings on the kidney was performed preoperatively in all cases. In 48 surgical cases, renal clearance was measured in both preoperative period and postoperative period, i. e. on the 3rd day, 1at, 2nd and 3rd week postoperatively.
The results are summarized as follows:
1) In 58 cases, regressive and inflammatory lesions were seen in the renal corpuscles; in 78 cases, in the tubuli; in 72 cases, in the interstitium and in 49 cases, in the blood vessels. However, the blood vessels were involved to a mild degree in most cases.
2) Involvements of the renal tubuli and interstitium were revealed severer with the age of the patients.
3) Severe involvements of the renal tubul; and interstitium were often encountered among the cases with the diseases complicating with urinary passage disturbance, e. g. prostatic hypertrophy, prostatic cancer, cancer of the urinary bladder etc.
4) Reduction in the values of the renal clearances in the preoperative period was noted in more cases than in the younger age group: The reduction was more prononced with the age of the patients.
5) Marked reduction in the values of the renal clearance tests was noted in cases with severe involvements in the renal tubuli and interstitium.
6) In many cases, especially in the cases with severe involvements in the renal tubuli and interstitium, G. F. R. and R. P. F. decreased markedly after the operation, as compared to the younger aged group. In these cases the decreased values of G. F. R. and R. P. F. were noted even in the preoperative period and reduced further in the postoperative period with delayed recovery of the values.
