ON THE STUDY OF THE IMPLANTATION OF ASCITES TUMOR IN URINARY BLADDER
REPORT III. THE METHOD OF THE TRANSURETHRAL IMPLANTATION IN URINARY BLADDER
1966 Volume 57 Issue 4 Pages 360-379
Details
1966 Volume 57 Issue 4 Pages 360-379
Transurethral implantation of Yoshida sarcoma and AH 130 hepatoma in the urinary bladder was attempted in rats. A vinyl tube, 1mm in diameter, which had a slight bent induced by a wire placed in the lumen of the tube, was introduced into the urinary bladder of female rats anesthesized by ether. Extreme care was taken not to injure the urethra and to prevet possible intra-peritoneal penetration. Ascites tumor was then injected in a quantity of 0.04cc through the tube.
The results obtaind are as follows:
1) Successful implantation was made in 34 of 47 cases (72.3%) in Yoshida sarcoma and in 34 of 45 cases (75.5%) in AH 130 hepatoma. Both Yoshida sarcoma and AH 130 hepatoma were implanted onto the bladder epithelium. Then, Yoshida sarcoma mainly grew infiltratively into the tief portion of the vesical wall, i. e., muscle tissue and serosa, while AH 130 hepatoma in greater part grew papillomatous into the vesical lumen like the growth of human papillomatous cancer.
2) Hydroureter, which indicates involvement of the ureteral orfice, was found in 55.8% in Yoshida sarcoma and 73.5% in AH 130 hepatoma. Ascites formation was noted in only 5.9% in both Yoshida sarcoma and AH 130 heaptoma.
3) Both in Yoshida sarcoma and AH 130 hepatoma metastasis was found in the resional lymphnodes and distant organs in many cases. In Yoshida sarcoma, lymphatic metastasis was seen in all the cases and metastasis to the lung, kidney, liver and spleen was revealed in 81.3-93.8%. However, metastasis was found less frequently in the internal genitalia and intestines: 43.8% in the former and 12.5% in the latter.
In AH 130 hepatoma lymphatic metastasis was found in 93.3%. The lung, liver and spleen was metastasized in 60.0-86.6%. In the internal genitaria, rectum and small intestine metastasis was found in 33.3%, 20.0% and 14.4% respectively.
4) Spreading ways of the implanted tumors were different according to the organs involved: the tumors spread lymphogenously to the retroperitoneal lymphnodes, hematogenously to the lung, liver and spleen, and continuously to the internal genitalien and rectum.
But the kidney was found to be involved both hematogenously and intracanalicularly.
