EXPERIMENTAL STUDIES OF RENAL TRANSPLANTATION IN DOGS

Abstract

In recent years, a considerable number of immunosuppressive procedures have been reported for the protection of the rejection in renal allotransplantation.
The present work is concerned with the examination in renal auto-and allotransplantation in dogs, and proposes a new immunosuppressive method.
The iliac fossa was selected as the allogenous transplanting site on the ground of the results of autotransplantation. The dogs with allotransplanted kidneys have been divided into three groups: 1) Unconditioned, 2) intramuscularly given 5mg of 6-Mercaptopurine (6MP) per one kg of body weight and 3) intravenously given the donor kidney digest with Nagarse in addition to the administration of 6MP. The mean survival of the animals of each group was 9.4, 6.4 and 6.7 days respectively. The results was not successful to prolong the survival, the findings of the allotransplants of the groups administered 6MP were, however, better than those of the control group.
One of the purposes of the work here is to protect the allograft rejection specifically by means of absorption of the antibodies with some antigenetically active substance, that is, the donor kidney digest. So far as known bibliographically, such an idea as above described has not ever been reported in renal transplantation, and should be more investigated concerning the condition of digestion and the selection of enzymes.