EXPERIMENTAL STUDIES OF THE EFFECTS OF URINARY DIVERSION AND ADMINISTRATION OF SOME CARCINOGENIC SUBSTANCES ON THE BLADDER
I. THE EFFECT OF URINARY DIVERSION ON THE BLADDER
1967 Volume 58 Issue 1 Pages 29-45
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1967 Volume 58 Issue 1 Pages 29-45
An experimental study was made on the effect of urinary diversion upon the bladder in 43 female adult mongrel dogs.
The results were as follows:
1) The atrophy of the bladder was seen 2 weeks after uretero-vaginostomy. Histological findings were the atrophy of the mucosal layer including concentration and degeneration of cells, the increase of collagenous fibers in the submucosal layer just below the mucosal layer and just above the muscular layer, the increase of metachromatic cells in the same area and the decrease of muscle fibers in the muscular layer. These findings were progressive day after day, and after 3 months, the increase of collagenous fibers and lattice fibers was noticed in the submucosal layer despite of the decrease of the elastic fibers. After 10 months, the disappearance of internal muscular layer, and the increase of the collagenous fibers and lattice fibers were seen.
2) By the observation of the bladder pouches, histological changes after 5 months were similar to those found 2 weeks after uretero-vaginostomy.
3) It is suspected that the mucosal layer maintains the secretory function because of subsistence of fluid in the pouches and PAS-positive substances in the mucosal layer.
