A STUDY ON TRANSPLANTATION OF THE KIDNEY

AN EXPERIMENTAL OBSERVATION OF WASHING BLOOD OUT OF THE DONOR KIDNEY

Abstract

Eleven varieties of irrigating solution which differ in constitution and temperature were evaluated to determine which is the most adequate in washing blood out of the donor kidney fast and completely.
1) Change of kidney weight before and after irrigation, flow rate of irrigants through the renal vein and elimination of hemoglobin were examined, and microangiographic study was made. Intrarenal vascularity was observed morphologically immediately after irrigation.
2) Irrigation of the donor kidney with physiological saline solution resulted in significant increase of kidney weight, and interstitial edema. No significant change was noted after irrigation with low molecular weight dextran.
3) Hemoglobin was washed out faster with irrigant which showed higher flow rate through the renal vein. Flow rate was little increased by adding heparin (50mg/l) to the irrigant.
4) Peripheral vascular spasm was noted in irrigation with irrigant without procaine. Addition of procaine (1g/l) reduced the spasm and increased the flow rate of irrigant significantly.
5) In groups with low molecular weight dextran, temperature of irrigant influenced the flow rate, higher flow rate being obtained by higher temperature (not above the body temperature).
6) It is concluded that 30°C or 37°C 10% low molecular weight dextran with procaine (1gm/l) and heparin (50mgm/l) added is the most adequate irrigant.