THE INCREASED VASCULAR PERMEABILITY AND FIBRINOLYTIC ENZYME SYSTEM IN UROLOGICAL FIELD

Abstract

Author made experiments on the fibrinolytic enzyme system and capillary permeability promoting action in serum (C. P. P. action) by Kuroyanagi in urological field, and commented on the relation between the fibrinolytic enzyme system, the kinin-releasing enzymes and these lytic products, and these vascular permeability action.
1) In the cases of so-called idiopathic renal bleeding, the high average of the activation of the fibrinolytic enzyme system and positive C. P. P. action were observed, and in the cases of hemorrhagic cystitis, the latter was observed.
2) In the cases who underwent transurethral resection of prostate, the fibrinolytic enzyme system was activated and positive C. P. P. action was observed.
Even if the fibrinolytic enzyme system recovered to normal value at the postoperation, C. P. P. action still remained.
3) The C. P. P. action increased after the treatment of prostate massage and this action was at its peak in the acid-treated serum.
4) In the animal experiments the C. P. P. action paralleled to the activity of the fibrinolytic enzyme system, and in the anaphylaxy shock the similar results in the relation of the C. P. P. action and the P. C. A. reaction was obtained.
5) The anti-plasmic drugs inhibited the C. P. P. action, especially the C. P. P. action ralating with the activation of the fibrinolytic enzyme system.
The mechanism suggested that the anti-plasmic drugs inhibited the vaso-active peptides produced from fibrinogen by plasmin.
6) In the inhibition of the anti-plasmic drugs on the vascular permeability of the leukotaxin-like substance, bradykinin and serotonin, t-amino-methyl-cyclohexan-carboxylic acid (t-AMCHA) inhibited the action of the leukotaxin-like substance, while ε-amino-caproic acid (EACA) inhibited that of serotonin, and mixed-AMCHA and EACA revealed respectively their higher effectiveness against that of bradykinin.
7) Reversely, bradykinin as representative kinin and serotonin as active amine had influenced on the fibrinolytic enzyme system.
It is supposed that in living body, the kinin-releasing enzymes, the kinins as its products and the kinin-releasing enzymes themselves reacted and regulated each other finely, and homeostasis was supported.
8) The C. P. P. action was of couse positive in the case of activated fibrinolytic enzyme, as well as occasionally even in the case of non-activated.
Many factors causing the C. P. P. action can be supposed and in the basic medical research they should be investigated drastically.