THE EFFECT OF VARIOUS DRUGS ON HUMAN URETER ELECTROMYOGRAM

Abstract

The effect of various drugs on ureters has been observed and reported by various ways.
However, studies using a ureter electromyogram have been few, since Hanley reported that the ureter peristalsis was inhibited by intravenous injection of Banthine. Furthermore such studies have been performed only on animals.
Recently, Tsuchida and Kimura described the first dependable method to record the electromyogram of human ureters employing intraureter leads.
Their method was adopted in this study, and the electromyographic changes by various drugs were observed on 50 adults who did not have any abnormality in upper urinary tracts.
The drugs employed were Ephedrine (40mg), Imidarin (20mg), Acetylcholine (100mg), Atropin (0.5mg), Buscopan (20mg), Atonin (0.5ml: 5-Oxytocin Units), Methergin (0.2mg) intramusculary, Vagostigmin (0.5mg and 1.0mg) intravenously.
The following results were obtained
1) Both sympathetic and parasympathetic stimulators tended to promote ureter peristalsis and their inhibitors acted oppositely.
2) The change of ureter peristalsis by the above agents was not excessive.
3) Involuntary muscle stimulating agents (Atonin, Methergin) also promoted ureter peristalsis, and its degree was most marked in the case of Atonin among all the agents described above.
4) There was no constant relationship between the urinary volume and the change of ureter peristalsis.