STUDIES ON LEUCINE AMINOPEPTIDASE (LAP) IN UROLOGICAL DISEASES
REPORT I. CHANGES OF LAP ACTIVITY IN RENAL HOMOTRANSPLANTS
1968 Volume 59 Issue 12 Pages 1084-1104
Details
1968 Volume 59 Issue 12 Pages 1084-1104
For the purpose of ascertaining relationships between changes in the urinary enzymatic activity and rejection of the homograft, the author has measured the activity of LAP, β-Glucuronidase, Lysozyme, and plasminogen activator. The study was performed on consecutive days for ten months, in six clinical cases of renal homotransplantation performed and followed at the Department of Urology, the Tokyo University Hospital.
In these measurements, activities of the four urinary enzymes increased and especially a specific increase in the level of urinary LAP, heralding a rejection, preceded a similar change in BUN Values. From the results of these experimental and clinical studies the following conclusions were made.
1. The measurement of urinary LAP activity may provide a worthy and reliable method of detecting renal homograft rejection in an early stage.
2. As this specific increase occurs 7 to 10 days prior to the clinical signs, the measurement of urinary LAP activity is helpful for the treatment and prognosis.
3. The measurement of LAP activity, in addition to other clinical examinations, is neccesary to perform, because of the rapidity (4 hours) and ease of LAP assay.
