LABORATORY AND CLINICAL STUDIES ON HIPPRAMINE
1969 Volume 60 Issue 1 Pages 71-79
Details
1969 Volume 60 Issue 1 Pages 71-79
Hippramine (Methenamine hippurate), a new antibacterial agent was studied both laboratorily and clinically.
The results were summarized as follows:
1) Urinary pH after oral administration of Hippramine at daily dose of 4.5g was kept below 5.5 and urine level of total formaldehyde reached about 500mcg/ml.
2) MIC of Hippramine against seven standard strains of E. coli, Proteus, Klebsiella, Pseudomonas, Staphylococcus and B. subtilis were 25-500mcg/ml at pH 5.5 and 1.000-4.000mcg/ml at pH 7.0.
3) Peak of MIC against 53 strains of urinary isolated bacteria was seen in 500mcg/ml at pH 5.5 and in 4.000mcg/ml at pH 7.0.
4) Antibacterial actions of urine obtained 3 hours after oral administration of 1.5g of Hippramine were 4-16 times stronger than the MIC of Hippramine against E. coli and Staphylococcus.
5) Clinical efficacy of Hippramine was evaluated in 26 cases of several urinary tract infections and concluded that Hippramine is effective in the treatment of urinary tract infections.
