EFFECTS OF PARATHYROID HORMONE ON THE MICROSOMAL FUNCTIONS OF RAT KIDNEY

Abstract

It is well known that parathyroid hormone affects renal functions. Recently, several workers reported the effects of parathyroid hormone on mitochondrial functions of liver and kidney in vitro. However, the biochemical mechanism of the hormonal action has not been established yet.
This paper deals with the effects of parathyroid hormone on microsomal functions of rat kidney in vivo.
Glucose-6-Phospatase activity was increased by injection of parathyroid hormone in the kidney microsomes, but was not in the liver microsomes. This increase was proved to be a specific and direct action of parathyroid hormone to the kidney microsomes by ineffectiveness of polypeptide and by independency of adrenocortical function. The increase was due to both the increase of the enzyme protein and functional change of the microsomal membrane, and it was dependent on protein and RNA synthesis.