HISTOCHEMICAL EVALUATION OF THE EFFECT OF RADIOISOTOPES ON DEHYDROGENASES IN LYMPH NODES

Abstract

Changes of the activities of succinic dehydrogenase, glucose-6-phosphate dehydrogenase and lactic dehydrogenase in lymph nodes were estimated histochemically in humans and rabbits.
1) The histochemical activities of those dehydrogenases were changed on the administration of radioisotopes before the histological changes by H. E. staining were not observed.
2) The staining intensities of those enzymes increased with lower radioactivity, while they decreased with higher one.
3) In rabbits, it was noted that the activities of those enzymes decreased markedly with a large dosis of the radioisotope.
Those results suggest that intralymphatic administration of radioisotopes might be useful in the treatment of malignancy and the prevention of tumor cell dissemination in lymphography. Further study would be necessary before we confirm the clinical effectiveness of this method.