EXERCISE AND FIBRINOLYTIC ENZYME SYSTEM
II The Fibrinolytic Activities of the Fresh Urine and The pH2-Treated Urine and The Urokinase
1969 Volume 60 Issue 6 Pages 529-540
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1969 Volume 60 Issue 6 Pages 529-540
The authors were studying on the fibrinolytic enzyme system (F. E. S.) in the blood and the urine influenced by the exercise.
Since Macfarlane et al. (1947)reported on the presence of F. E. like substance in human urine, it was recognized that this substance is the activator of plasminogen (urokinase: UK).
The standard values of the fibrinolytic activities of fresh and acid-treated urine, U. K. extracted by thiocyanate in healthy human, and the relationship between these F. E. S. in urine and the exercise are described in this report.
1. It is pronounced that the UK involved in normal human urine is varied by age and sex.
In healthy women aged 18 or 19, the mean lysis-area of the fresh urine on the standard fibrin-plate was 262.3mm2(±35.6mm2) (155 cases), that of the acid-treated urine 57.5mm2(74 cases), and that of UK 85.9mm2(±35.6mm2) (95 cases).
2. The change of F. E. S. in urine was influenced by the exercise:
1) The fresh urine;
In the group of its lysis-area below 300mm2 before the exorcise, its activity increased after the exercise, and in the group of that over 300mm2 before exercise, it decreased.
2) The urokinase;
In the group of its lysis-area below 100mm2 before the exercise, its activity increased after the exercise, especially that below 50mm2 increased significantly. In the group of that over 100mm2, its activity increased significantly after the exercise.
3) The acid-treated urine;
In the group of its lysis-area below 200mm2 before excrcise, its activity increased after exercise, and in the group of that over 200mm2 before exercise, that decreased significantly.
These fibrinolytic activities of urine were observed to show tendency to approach normal values after exercise.
3. The relation between the change of microhematuria and the F. E. S. in urine was influenced by the exercise:
In the group where microhematuria appeared first after the exericse and where microhematuria after the exercise was observed unchanged as before, the fibrinolytic activity of fresh urine increased after exercise. And in the group where the microhematuria was not observed before or after the exericse and where it decreased after the exercise, its activity decreased after exercise.
The activity of acid-treated urine decreased after the exercise in both groups, but in the group where the microhematuria after exercise was not observed, its decreasing tendency was stronger than in the other group.
On the contrary, the U. K. increased after the exercise in the group, where the microhematuria was not observed after the exercise, and the U. K. decreased in the other group.
In comparison of these activities with the involving grade of microhematuria without exercise, its, activities of fresh urine and acid-treated urine was related to the involving grade of microhematuria.
4. The relation between the grade of the albuminuria and these activities:
The activity of freah urine with albuminuria of 30mg/100ml was strongest, and the activity of acid-treated urine without protein was stronger than its activity of albuminuria.
The U. K. in the urine with protein of trace was most abundant, and that of protein of 30mg/100ml and without protein was low.
5. The relation between pH of urine and these activities:
The lysis-area of fresh urine ranged pH 6.6-7.0, below 5.0, 6.1-6.5, 5.1-5.5, and 5.6-6.0. The power of U. K. ranged from pH 6.1-6.5, to below 5.0, and that of acid-treated urine ranged pH 5.1-5.5, below 5.0, 5.6-6.0, 6.1-6.5, 6.6-7.0 of urine.
Especially, the lysis-areas of U. K. below pH 5.5 were more extensive than that of acid-treated urine.
6. There was no relation between these activities of fresh urine, acid-treated urine and U. K.
7. The relation between the menstrual cycle and these activities:
These activities in s
