STUDIES ON THE CHEMOTHERAPY OF CANCER OF URINARY BLADDER
REPORT II. AN EXPERIMENTAL STUDY ON TREATMENT WITH CONTINUOUS INFUSION OF ANTICANCER AGENT INTO THE INTERNAL ILIAC ARTERY
1969 Volume 60 Issue 7 Pages 657-666
Details
1969 Volume 60 Issue 7 Pages 657-666
In the treatment of cancer of the urinary bladder, effects and side effects of anticancer agent through various routes of administration were studied.
1) In four groups of dogs, 1mg/kg of Mitomycin C was administered as follows;
Group 1. Systemic administration
Group 2. One shot injection into the internal iliac artery
Group 3. Infusion into the lumen of the urinary bladder
Group 4. Continuous injection into the internal iliac artery
2) Mitomycin C was demonstrated in the bladder tissue in low concentration in groups 2 and 4, but not at all in groups 1 and 3.
3) Concentration of Mitomycin C in blood followed the order of group 1, 2, 4 and 3.
4) The phosphorylase and succinic dehydrogenase activity in the bladder tissue showed decrease in the order of group 4, 2, 3 and 1.
5) Side effects were noted to be severe in the order of group 1, 2, 4 and 3.
6) Continuous infusion of anticancer agent into the internal iliac artery gave the most intense destructive effects on bladder tissue with relatively mild systemic side effects, representing a reasonable method of administration of anticancer agent.
