A STUDY ON THE TREATMENT OF BLADDER CANCER

PART 1. BASIC STUDY ON THE CONTINUOUS INFUSION INTO INTERNAL ILIAC ARTERY FOR BLADDER CANCER

Abstract

In order to carry out the intraarterial infusion of carcinostatic substance into the internal iliac artery for progressive bladder cancer, basic experiments were carried out using dogs. The following results were obtained. i) After intravenous injection of one shot of MMC, the maximum concentration in blood shows a difference between the artery and the vein. The concentration in the artery was about twice as high as that in the vein. ii) Upon injection of MMC into the internal iliac artery, an extremely high concentration in the cystic artery blood was obtained. Moreover, upon ligation of the internal iliac artery, local concentration in blood became approximately 3 times that obtained without ligation. iii) Concentration of MMC in the tissue of the organ was very low as compared with the concentration in blood. Generally speaking, the concentration was lower in the liver an renal cortex but high in the renal medulla. Upon administration into the internal iliac artery, MMC concentration in bladder tissue became high. The highest value was obtained in the lateral wall of the cervix. iv) While the liver, renal cortex and bladder tissue had a considerably anti-MMC property, MMC inactivation was weak in the renal medulla. Even by a low concentration of MMC, its tissue metabolism was not abnormal. v) Most of the human bladder tumor tissues appear to be sensitive to MMC. The minimum effective concentration and time of contact was about 1mcg/ml and 10 minutes respectively. vi) In clinical application of this method, ligation of internal iliac artery, MMC concentration of 100mcg/ml, speed of injection of 4ml./min, and time of injection of 10 minutes in intermittent administration appear to be adequate.