TRANSPORT OF ANTIBACTERIAL DRUGS INTO THE CANINE BLADDER WALL; ITS SIGNIFICANCE IN EVALUATION OF ANTIBACTERIAL DRUGS IN URINE FOR THE TREATMENT OF URINARY TRACT INFECTION

Abstract

Many works have been published on the absorption of various drugs by the bladder wall. Nevertheless, there were very few literatures regarding the transport of antibacterial drugs in the bladder wall, especially antibiotics.
In regards to the transmission of antibacterial drugs to the bladder wall, two routes are theoretically inferred, namely through the blood supply to the bladder Wall and through the reabsorption of the drugs by the bladder wall. The present study was designed to delineate the quantitative transport of antibacterial drugs with the emphasis on the reabsorption of antibacterial drugs into the bladder wall of the dog.
1. It was observed that Tetracycline, Colimycin and Streptomycin instilled in the bladder cavity, were transported into the bladder tissue, and were recovered in the urine through the blood stream.
2. These transports were not obviously influenced by PH or the osmolality of the solution for instillation of these drugs.
3. Intravesical pressure did not seem to augment the transport of these drugs in the normal bladder, but, a significant increment of transport were noticed in the inflammatory bladder during the increase of intravesical pressure.
4. Antibiotics instilled in the bladder cavity were transported more effectivelly in the inflammatory bladder than in the normal bladder.
5. The higher the concentration of instilled antibiotics, the more antibiotics were transported to the bladder wall.
6. The antibiotics in the bladder wall were carried through the blood stream as well as urine.
This tendency was more marked in the inflammatory bladder.
7. In conclusion, drugs of higher concentration in the urine are inferred to be more effective for urinary tract infection, especially inflammation of the bladder.