1971 Volume 62 Issue 9 Pages 679-682
For the purpose of predicting the clinical response following antiandrogenic treatment, a study was performed on the alterations with time of the SLDH activity as well as of its isoenzyme pattern accompanied with massage of the prostate in a series of 26 patients with prostatic carcinoma. The results were as follows: 1) Between the fairly responsive cases and the poorly responsive ones, SLDH activity prior to massage of the prostate showed no significant difference. Following massage of the prostate, increase of SLDH activity was significantly higher in the poorly responsive patients than the fairly responsive ones 1 to 8 hours after the massage. 2) Average premassage control levels of SLDH isoenzyme IV and III fractions were 1.77±0.39% and 24.47±1.40%, respectively, in the fairly responsive patients and 3.72±1.95% and 31.90±1.69% in the poorly responsive patients, being significantly higher in the latter. These differences served previously to differentiate the clinical response to antiandrogenic treatment between both groups. 3) Increase of SLDH isoenzyme V and IV fractions following massage of the prostate was significantly higher in the poorly responsive patients throughout the period of experiment, with exception for the 1 hour specimen, than in the fairly responsive patients. 4) For both experimental groups, alterations of SLDH isoenzyme II and I fractions were not useful for the prediction of clinical effects.
