1972 Volume 63 Issue 11 Pages 951-971
I applied β-glucuronidase (β-G) inhibitor in urine, 2, 5-di-o-acetyl, D-glucaro (1-4) (6-3) dilactone (SLA), which was produced on Boyland's hypothesis, for the purpose of preventing recurrence after operation of bladder tumor.
Comparing the group of forty-four cases given SLA in low grade and low stage with another group of fifty-two cases not given SLA, I examined the rate of recurrence by analyzing the various factors, the fluctuation of β-G activity and the amount of glucaric acid in urine by using SLA in bladder tumor patients before and after operation: I also examined the relationships between β-G activity and o-glucuronide.
1) β-G activity in urine of bladder tumor patients showed higher numerical value than that of the normal control.
2) β-G activity in urine was remarkably decreased by applying SLA, and was fully checked for a three year's duration.
3) No difference was seen about the amount of excretion of glucaric acid in urine between bladder tumor patients and normal controls.
4) By applying SLA, the amount of exretion of glucaric acid in urine was remarkably increased, amounting to about 150mg/day and no difference was seen during the period of the application of SLA.
5) The amount of excretion of loaded Salicylamide-o-glucuronide tended to be larger at high β-G activity than low β-G activity in urine.
6) By administration of SLA, the recurrence rate of bladder tumor more than two years after the operation was significantly lower than in the non-SLA group. However, the recurrence rate soon after the operation showed no difference.
7) The most striking effect by administration of SLA was recognized in single, peduncurated and small sized tumors.
8) Some effect of preventing the recurrence soon after the operation by instillating anti-cancer drugs into the bladder was recognized.
9) Combining the therapy with SLA-administration and instillation of anti-cancer drugs into the bladder was more effective than the separate use of either alone.
10) Combining the therapy with administration of SLA and Vitamin B6 was also more effective than the separate use.
