1973 Volume 64 Issue 3 Pages 231-237
The technique of Rn seed radiation hypophysectomy by the paranasal transethmoid-sphenoidal approach is described. The clinical effects, side effects and prognosis in 20 patients with prostatic carcinoma treated by this technique are described. The clinical results were good in 11 cases, fair in 6 cases and poor in 3 cases, giving an improvement rate of 85%. The beneficial results were most impressive against pain. Side effects such as optic nerve disturbance, polyuria and rhinorrhea were noted but these were mild. This method appears to be especially effective in patients with progression of tumor and pain after endocrine therapy. This method is recommended since the morbidity is minimal.