HYDROSTATIC PRESSURE TREATMENT FOR MALIGNANT LESIONS OF URINARY BLADDER
1973 Volume 64 Issue 4 Pages 324-337
Details
1973 Volume 64 Issue 4 Pages 324-337
“Hydrostatic pressure method” proposed by Helmstein (1972) was applied on 6 cases of transitional cell carcinoma in urinary bladders with successful and fruitful results.
Cystoscopically, tumors of the urinary bladder completely disappeared on from the 30th to 60th day after the procedure. Only 1 case out of 5 cases with repeated biopsies showed remnant tiny carcinoma nests. Preoperative biopsy of the same case revealed sessile transitional cell carcinoma with extensive infiltration into the deeper stroma. After the treatment, lymph-follicle formation was obviously noticed beneath the epithelial layer regenerating over the areas in which tumors might pre-exisit.
Mechanism of the treatment should be explained partial ischemic necrosis of tumor lesions caused by circulatory disturbances following tumor immunity activation. These process in human neoplasms would be compatible with phenomena of tumor immunity developed by “strangulation method” in rats (Lewis, 1952) or of “ligation-release procedure” in rats (Takeda, 1967).
