PROSTAGLANDIN AND RENAL FUNCTION

(III) The Effect of PGA₂, on the Urinary Solutes Excretion

Abstract

1) Twenty-nine cases without upper urinary tract dilatation and renal impairment were studied on urinary solutes excretion induced by PGA₂.
2) An intravenous infusion of PGA₂ with the rate of 400ng/Kg/min. caused marked increases of urine volume and urinary excretion of both sodium and chloride. Especially as for sodium excretion, more increase was observed among hypertensives than normotensives.
3) The same effect of PGA₂ was observed at the state of dehydration followed by an intramuscular injection of 5 units of vasopressin. U_osm decreased slightly, while C_osm and T^C_H2O increased.
4) These effects of PGA₂ on urinary solute excretion were supposed to be due to the fact that PGA₂ increases the renomedullary blood flow and inhibits the sodium reabsorption at the proximal tubuli.