CARCINOMA IN SITU OF THE URINARY BLADDER

CLINICAL CASES SIMULATING CHRONIC CYSTITIS

Abstract

Seven cases of carcinoma in situ of the urinary bladder and infiltrative bladder cancer which developed from carcinoma in situ were reported. Our experience and review of literature on this subject show that carcinoma in situ of the urinary bladder simulates chronic cystitis not only in symptoms and cystoscopic findings but also in histological findings of biopsy specimens. Probably due to decreased intercellular cohesiveness, in situ urothelial carcinoma cells exfoliate easily into urine and characteristic histological feature of denuding cystitis, namely denudation of urothelium and submucosal edema and teleangiectasia, is produced. Nontuberculous, abacterial stubborn cystitis with positive urinary cytology strongly suggests carcinoma in situ of the urinary bladder and should be treated as such until otherwise proved.