1975 Volume 66 Issue 10 Pages 656-660
With the aim of establishing methods for the prevention of recurrent formation of urinary oxalate containing calculi, the author made the following examinations.
1) Statistics on the composition of calculi, causative disease, and recurrence in 884 patients with upper urinary tract calculi.
2) Statistical studies on uric acid metabolism in 63 patients with oxalate containing calculi.
The following results were obtained.
1) Analysis of calculus composition in 299 of the 884 cases showed that there were 136 cases of calcium oxalate-calcium phosphate calculi, 70 cases of calcium oxalate calculi, and 31 cases of calcium oxalate-ammonium magnesium phosphate calculi. Causative disease was established in 199 cases, including 125 cases of hyperuricemia, 16 cases of sponge kidney, and 14 cases of calyceal diverticulum. The recurrence rate for all 884 case was 16.6%; while that for the 191 cases of known etiology was 33.5%, the rates according to specific diseases being 4 out of 7 cases in cystinuria, 5 out of 9 cases in hyperparathyroidism, and 46 out of 125 cases in hyperuricemia.
2) High frequency of recurrence was seen in patients with hyperexcretion of urinary uric acid (over 700mg/24 hours) viz, in 18 out of 32 cases. On the other hand, only 6 out of 31 cases of recurrence were seen among a group of hyperuricemics with normal urinary uric acid excretion.
The results suggest a relation between hyperuricosuria and oxalate containing calculi formation, irrespective of serum uric acid value.
