IMMUNOLOGICAL STUDIES ON MOUSE TESTICULAR TUMOR

HUMORAL ANTIBODY RESPONSE AGAINST TESTICULAR INTERSTITIAL CELL TUMOR IN TUMOR-BEARING MICE

Abstract

An estrogen-induced testicular interstitial cell tumor (TICT), originated in an A strain mouse testis and maintained in A/St mice, was converted into an ascitic form in A/St mice in our laboratory.
The humoral antibody response to the ascitic TICT in ascitic TICT-bearing mice was demonstrated by sensitive immune adherence reaction.
The antibody reactive transplantation antigen on the ascitic TICT was indicated to be tumor specific.
The antibody response of the tumor-bearing hosts was maximum at their terminal stage of tumor-bearing state and it was even higher than that of the mice which had been immunized subcutaneously with ⁶⁰Co irradiated ascitic TICT cells and resisted against an intraperitoneal transplantation of non-treated tumor cells.
The significance of these results was discussed.