KALLMANN'S SYNDROME

REPORT OF TWO CASES

Abstract

Two cases of Kallmann's syndrome (hypogonadotropic hypogonadism with anosmia) are reported.
Case 1: A 23-year-old man visited our hospital on Aug. 27, 1973, with the chief complaint of a small penis. In his early infancy he apparently was normal except he could not walk until four years old. He noticed the alterations in his genitalia from the latter half of his elementary school days. Plasma levels of pituitary follicle stimulating and luteinizing hormones, as determined by radioimm. unoassay, were low, and the level of the latter hormone did not rise even after administration of luteinizing hormone releasing hormone. A testicular biopsy showed an immature testis and the Leydig cells were not observed. The diagnosis of right renal aplasia and anosmia was also established and right testicular aplasia was suspected.
Case 2: A 25-year-old man visited our hospital on May 13, 1974, with the chief complaint of evaluation of a small penis. In his birth history and early infancy he was apparently normal. Although he noticed the change of voice and rapid growth after graduation of junior high school, the penile development was not noticed. Plasma levels of pituitary follicle stimulating and luteinizing hormones were low, and the level of the latter hormone hardly rose, following administration of luteinizing hormone releasing hormone. A testicular biopsy showed an immature testis, and tests for olfactory sense revealed anosmia.