ALKALINE PHOSPHATASE SECRETING RENAL CELL CARCINOMA WITH SOME SPECULATION ON ALKALINE PHOSPHATASE ISOZYME ORIGINATING FROM KIDNEY
1976 Volume 67 Issue 1 Pages 14-20
Details
1976 Volume 67 Issue 1 Pages 14-20
A 47 year-old female was admitted to the Hospital because of unknown fever and general malaise. She was found to show extremely high serum alkaline phosphatase (Al-P) without metastasis or cardiac insufficiency, which came down to normal with improvement of clinical symptoms 2 weeks after surgery.
Electrophoretic study of alkaline phosphatase from serum, urine, normal renal cortex and tumor confirmed that elevated activity of serum alkaline phosphatase was caused by the tumor itself. Alkaline phosphatase isozyme secreted from the tumor was spotted at the same area at Al-P1 by the current gel agar method. On the other hand alkaline phosphatase isozyme from normal renal cortex appeared at the same area as Al-P3 on electrophoresis. However, it was proved to be different from Al-P3 by the inhibition tests by phenylalanine, urea, EDTA and heating.
