1976 Volume 67 Issue 11 Pages 911-917
1) A course of bladder instillation of 400mg FT-207 (40ml of 10% solution of FT-207) was given 3 times weekly for a total of 20 procedures to 21 patients with bladder tumors. In one patient the tumor disappeared completely, in 2 patients there was partial disappearance and in the 18 other patients no effect was observed. The total effective rate was, therefore, 14%.
2) An experimental study of the instillation of 500mg./kg. FT-207 into the bladder of 11 adult male rabbits was performed. The drug was detected in small amounts in blood samples (35.2mcg./ml. as FT-207, 0.032mcg./ml. as 5-FU), and in greater amounts in the bladder wall (1075.6mcg./g. as FT-207, 4.76mcg./g. as 5-FU) and regional lymphnodes (45.3mcg./g. as FT-207, 0.178mcg./g. as 5-FU) one to two hours later. Similiar results were observed in 7 patients treated with cystectomy after bladder instillation of FT-207. It was considered, accordingly, that lymphatic absorption of FT-207 had occurred through the mucous membrane of the bladder wall.
3) In both the experimental and clinical studies, the concentration of 5-FU in the bladder wall and the regional lymphnodes was found to be 60-300 times larger than the concentration in the blood 1 hour after bladder instillation of FT-207. This suggested that FT-207 absorbed into the tissues was converted to 5-FU in the tissues themselves as well as in the liver.
4) It was concluded that bladder instillation therapy of FT-207 before surgery might result in an improvement of postoperative prognosis because an effective dose of 5-FU could be distributed into the deep part of the bladder wall and the regional lymphnodes.
