STUDIES ON RENAL HYPERTENSION SIGNIFICANCE OF RATIO OF K TO Na CONCENTRATION IN DIVIDED URINE IN EXPERIMENTAL HYPERTENSION PRODUCED BY COARCTATION OF THE AORTA
1977 Volume 68 Issue 12 Pages 1119-1126
Details
1977 Volume 68 Issue 12 Pages 1119-1126
Divided renal function studies were performed in experimental unilateral renal hypertension in dogs. Renal ischemia of the left side was produced by coarctation of the aorta between the ramification of renal arteries with a modified Galen's technique.
1. In the condition of a 27 to 68 per cent decrease of systolic blood pressure in the femoral artery by aortic coarctation, significant hypertensive state was induced in 3 to 4 weeks postoperatively and sustained up to 8 weeks.
2. Results of divided renal function studies were as follows. Decreases of GFR, urine volume, Na concentration and TRF-Na were observed, as well as increases of PAH, creatinine and K concentrations, and osmolarity in urine of the ischemic kidney.
3. Ratio of K/Na urinary concentration in the right to left kidney (U-K/Na Index). The value of this index was 0.35±0.14 and a highly significant correlation between this Index and TRFR was found (r=0.892, p<0.001).
4. U-K/Na Index is valuable as a clinical examination in the diagnosis of unilateral renal artery stenosis.
