Abstract
In spite of numerous studies on chemotherapy for pyelonephritis, the renal distribution of the adminstered antibiotics is not yet completely understood. In order to examine this, using experimentally induced unilateral pyelonephritic dogs, the antibiotics concentration in the renal tissue was measured with relation to that in both urine and serum after single intravenos injection of Cefazolin (50mg/kg). This experiment was performed in both acute and chronic stages of pyelonephritic dogs.
The results were as follows.
1. A half life of the serum concentration was more prolonged in both acute and chronic unilateral pyelonephritic dogs than in the normal group.
2. In unilateral acute pyelonephritic dogs which showed a mild type of inflammation, the tissue concentration was higher and both urinary concentration and excretion rate were lower in the affected kidney than in the control kidney of the other side. Furthermore, the decreasing rate of tissue concentration curve was found to be slightly low. On the other hand, when the inflammation was so severe as the abscess formation was dominant, the affected kidney showed low levels of the tissue concentration, the urinary concentration and the excretion rate.
3. In unilateral chronic cases, the renal tissue concentration, the urinary concentration and the excretion rate were lower in the affected kidney than in the normol kidney of the other side.
These results suggested that the high distribution and the long retention of the antibiotics were obtained in the inflammatory area of the renal tissue only when the infection was acute and mild. However, in the cases of severe acute pyelonephritis and chronic pyelonephritis, the renal tissue distribution seemed to be low, and in both acute and chronic pyelonephritic kidneys, the urinary excretion seemed to be decreased.
