1977 Volume 68 Issue 8 Pages 731-736
In order to investigate the role of l-tryptophan's promoting factor on tumorgenesis in the urinary bladder, the following experiment was contemplated.
Sixty D-D strain female mice of 7-week-old were fed 0.1% FANFT added CE-2 diet for 4-week duration. Thereafter, these mice were divided into two groups each comprising thirty mice 0.2% l-tryptophan added CE-2 diet for one group (group-1) and CE-2 diet for another (group-2) were fed for those mice in respective groups for another 56 weeks.
Results:
1) There were two cases of bladder tumor among the group-1 mice.
2) Both labeling index and hyperplastic index were statistically significant (t=2.78, p<0.05) in group-1 mice when compared with group-2. From these results L-tryptophan's promoting factor on tumorgenesis in the urinary bladder seemed to be undeniable.
