1977 Volume 68 Issue 8 Pages 751-757
CEA (carcinoembryonic antigen) determinations were performed on 96 patients with urologic dis-ease. The results were compared with 83 patients of disease of another organs which was mainly cancer of digestive tract.
CEA of 211 serum and 37 urine samples were determined by “one step sandwich method” which was radioimmunometric assay for serum CEA.
By this method, the normal range was 0 to 2.5ng of CEA per 1ml of serum, and 0 to 1.5ng of CEA per 1ml of urine.
CEA was elevated in 28 (62%) out of 45 patients, mean value of CEA was 3.2±2.3ng/ml in the patients with urologic active cancer. On the other hand, CEA was elevated in 9 (25%) out of 36 patients with benign urologic disease, mean value of CEA was 1.8±1.0ng/ml in this group.
Value of serum CEA in patients with cancers of the lower digestive tract, lung and others was more elevated than the value of CEA in patients with urologic active cancer.
CEA determination was perfomed before and after the therapy for 5 to 10 weeks on the 12 patients with urologic cancer, as value of CEA was almost paralleled with clinical states.
In 37 patients, both urine and serum CEA levels were determined. Value of CEA in serum was below 2.5ng/ml in 25 patients. Mean value of CEA in urine was 0.8±0.3ng/ml in normal subjects, and 2.2±1.0ng/ml in 4 patients with urologic cancer who had no evidence of urinary tract infection. In cases with urinary tract infection, however, urinary CEA was elevated with an average of 4.4±3.3ng/ml in 12 patients.
